Spleen White Pulp

This section of the white pulp shows a central artery surrounded by peri-arteriolar lymphatic sheath (PALS), which is a T-cell zone. It is common to find B-cell lymphoid follicles closely associated with PALSs. The follicle here is a secondary follicle, as evidenced by the presence of a pale-staining germinal center. The germinal center is surrounded by a narrow ring of deep-stained mantle that contains resting B-cells. The marginal zone separates the follicle from the red pulp.