Lymph Node Paracortex
Lymph Node Paracortex

Lymph Node Paracortex

The paracortex of the lymph node is a T-cell zone. One feature of this region is the high endothelial venule, where circulating lymphocytes leave the bloodstream to enter the node. These postcapillary HEVs can be distinguished by their cuboidal endothelial cells. Adhesion molecules called selectins and integrins on the surfaces of HEVs and lymphocytes mediate attachment of lymphocytes to endothelial cells. In a T cell-dominant immunological response, one may observe expansions of the paracortical region. How does the lining of HEVs differ from that of normal blood vessels?
Answer: Most capillaries have squamous endothelial cells, but HEVs have cuboidal endothelial cells.