Chronic Myelogenous Leukemia

Chronic Myelogenous Leukemia (CML) is a form of leukemia caused by a chromosomal translocation known as the Philadelphia chromosome, which you will study in detail in Genetics. It is characterized by the unregulated growth of myeloid cells in the bone marrow, resulting in the presence of large numbers of mature and immature granulocytes in both the bone marrow and the blood.